「“senescent”」的含义 (adjective)
词性(英语单词分类):形容词
生物学
专门
它用来表示“旧的、状况不佳且不再起作用”。
中文翻译:[老年]
参考:「senescent」示例短语列表
“senescent”的同义词列表。 让我们按顺序来记住吧!。
通过记住反义词和反义词列表来掌握“senescent”这个词!。
“senescent”是一个英语单词,有几个不同的含义。 让我们用例句来解释每个的含义和用法!
| 英语 | 含义(中文翻译) | 详细解释! |
| senescent | 老龄化,老年人 | (老化) |
senescent是一个英语单词,有几个不同的含义。 让我们用例句来解释每个的含义和用法!
It has been suggested that by secreting various proteins,
senescent
cells may accelerate the proliferation and malignant transformation of surrounding cancer cells.
有人提出,
衰老
细胞可能通过分泌各种蛋白质来促进周围癌细胞的增殖和恶变。
In mice lacking functional CCN1, fewer
senescent
cells appear.
缺乏功能性CCN1的小鼠仅发育出少量的
衰老
细胞。
Jun and Lau find that in mice
senescent
cells appear in the granulation tissue – the soft connective tissue that forms in the wound during healing.
J Jun 和 L F Lau 发现,小鼠的肉芽组织中出现了
衰老
细胞,肉芽组织是伤口愈合过程中形成的结缔软组织。
Diana Jurk and colleagues show that
senescent
liver cells cannot break down fat cells as efficiently as normal liver cells, which promotes fat accumulation in the liver of mice.
Diana Jurk 及其同事对小鼠进行了一项研究,发现
衰老的
肝细胞分解脂肪细胞的效率不如正常肝细胞,这会促进肝脏中的脂肪积累。
One of the changes in cancerous cells caused by this treatment is the appearance of
senescent
cells.
癌细胞因治疗而发生的变化之一是
衰老
细胞的出现。
When telomeric DNA is shortened to a certain length, a cell irreversibly stops dividing and becomes a
senescent
cell.
当端粒DNA缩短到一定长度时,细胞不可逆地停止分裂并成为
衰老
细胞。
(Fig.)Schematic model of the regulation and function of sEV-associated EphA2 in
senescent
cells.
(图)
衰老
细胞分泌的外泌体样囊泡含有膜样EphA2,它通过靶细胞中的ephrin-A1促进细胞增殖。
Regulation of tumorigenesis by cellular senescence.During the past few decades, we have revealed that p16INK4a cyclin-dependent kinase inhibitor has a key role in establishing stable G1 cell-cycle arrest through activating the retinoblastoma (Rb) tumor suppressor protein in
senescent
cells (Hara et al., Mol.
(细胞衰老研究背景及最新动态请点击此处。) 1. 细胞衰老及其分解抑制癌变的机制 我们在全球率先使用细胞周期蛋白依赖性激酶抑制剂诱导细胞
衰老
。 p16INK4a 发挥着重要作用,通过激活肿瘤抑制基因产物 pRB 来阻止细胞增殖,同时通过产生活性氧 (ROS) 来调节细胞衰老的不可逆性。(Hara et al., Mol.
The presence of SAHF dampens the response to damaged DNA to sublethal levels, permitting cells to stop dividing and become
senescent
rather than die.
当 SAHF 存在时,对受损 DNA 的反应会降低到致死水平以下,细胞会停止分裂和
衰老
,但不会死亡。
Researchers also found that accumulation of
senescent
cells in affected tissues was blocked by treatment with the anti-inflammatory drug ibuprofen or with antioxidants, which rescues the tissues’ ability to regenerate.
Zglinicki 及其同事还发现,服用抗炎药布洛芬和抗氧化剂可以防止发炎组织中
衰老
细胞的积累,并恢复组织的再生能力。
They hypothesize that this is due to enhanced telomere shortening due to DNA damage from reactive oxygen species-chemically reactive molecules containing oxygen-and that this in turn accelerates the accumulation of
senescent
cells.
至于原因,Zglinicki 及其同事推测,活性氧(含氧的化学活性分子)会损伤 DNA,从而缩短端粒,从而加速
衰老
细胞的积累。结果显示。
EphA2 expressed on the surface of
senescent
cell sEVs bind to ephrin-A1 that is highly expressed in several types of cancer cells and promotes cell proliferation by activating the Erk pathway through EphA2/ephrin-A1 reverse signalling.
这项研究发现,
衰老
细胞分泌的细胞外囊泡上的EphA2增加,并与细胞膜上经常上调的ephrin-A1结合,从而激活Erk信号。结果表明,癌细胞的生长被提升了。
The robust activation of an IFN-I response is a novel phenotype of
senescent
cells, that is shown to contributes significantly to the so-called senescence associated secretory phenotype.
IFN-I反应的强烈激活已被证明是
衰老
细胞的新表型之一,对所谓的衰老相关分泌表型有显着贡献。
In their previous research, Professor Matozaki’s research group discovered that when the protein SIRPa, which is expressed on the cell membrane of macrophages, interacts with the protein CD47 which is expressed on the cell membrane of engulfment targets (such as cancer cells and
senescent
cells), the engulfment ability (phagocytosis) of the macrophages is inhibited (figure 1).
研究成果 Matozaki教授的研究小组迄今为止发现,当巨噬细胞细胞膜上的蛋白质SIRPa与吞噬目标细胞(例如癌细胞和
衰老
细胞)细胞膜上的蛋白质CD47结合时,发现巨噬细胞吞噬作用被抑制(图1)。
Additionally, it has been reported that one of the causes of individual aging is the accumulation of
senescent
cells.This means that drugs which control cell senescence could have potentially large benefits for the development of anti-aging medication products related to health and beauty.
另外,实验结果表明,个体衰老的原因之一是
衰老
细胞的积累,因此抑制细胞衰老的药物作为抗衰老产品,可以极大地促进美容健康相关产品的开发。性别。
Emerging evidence, however, reveals that
senescent
cells also promote secretion of various inflammatory and pro-proliferative factors.This newly identified senescence-associated phenotype termed SASP is likely to be associated with homeostatic disorders including cancer.
然而,另一方面,经历细胞衰老的细胞(
衰老
细胞)通过引起称为SASP的现象来抑制炎症,SASP高表达炎症细胞因子、趋化因子、生长因子和细胞外基质降解酶等各种分泌因子。人们还清楚地认识到,存在诱发癌症和促进癌变的副作用。
If we can develop a drug that targets and regulates the activity of the genes that control senescence identified in this research, by administering it together with conventional anticancer treatment we can limit the emergence of
senescent
cells and potentially increase the effectiveness of cancer treatment.
如果能够开发出针对本次鉴定出的细胞衰老控制基因并控制其活性的药物,则可以通过与常规抗癌药物治疗相结合来预防
衰老
细胞的出现,从而治疗癌症。预计效率将显着提高。
In anticancer treatment, drugs are carried to the cancerous tissue via the bloodstream.The researchers predicted that differences in concentrations of the anticancer drugs would arise based on the distance of the cells from the blood vessels, and so even in the normal cancer treatment process
senescent
cells would emerge.
在抗癌药物治疗中,药物通过血流运送到癌组织,因此预计抗癌药物的浓度会根据距血管的距离而有所不同,甚至在正常的癌症治疗过程中,
老化
细胞也会受到影响。预计会出现。
In oncogene-induced
senescent
(OIS) cells, MCAF1 is recruited to PML bodies through binding to SUMO2/3.This may inhibit MCAF1 function to maintain expression of cell cycle genes and histones (right).
(右)在癌基因导入诱导的
衰老
细胞中,MCAF1 移动到 PML 小体,使其无法激活组蛋白和细胞周期基因的表达,导致细胞衰老。
There were 126 genes where three times as much expression was recorded under treatment B compared to A, and 25 genes that showed twice as much expression in B compared to C. These 25 genes are expected to express specifically in
senescent
cells since the other factors caused by DNA damage are removed, and researchers confirmed that the genes involved in causing cell senescence were among them.
与条件A相比,在条件B下表达量增加了3倍以上的基因有126个,与条件C相比在条件B下表达量增加了2倍以上的基因有25个。这25个基因是在细胞
衰老
过程中表达特异性增加的基因,消除了DNA损伤的二次效应,我们证实其中一些基因在细胞衰老中发挥作用。
听听“ senescent ”的土声(发音)!
读法是【sɪˈnes.ənt】。 听下面的视频并大声发音【sɪˈnes.ənt】。

